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Glutathione biosynthesis occurs in two sequential, ATP-dependent enzymatic steps that take place in the cytosol: Step 1: The enzyme glutamate-cysteine ligase (GCL) combines glutamate and cysteine to form gamma-glutamylcysteine

Multiple studies highlight KP metabolites as potential biomarkers of clinical severity and suicidality in MDD

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A common feature of neurodegenerative diseases, such as Parkinsons disease, Alzheimers disease, MS, and ALS is extensive evidence of oxidative stress, which might be responsible for the neuronal dysfunction and death contributing to pathogenesis of these disorders (reviewed in Refs